Influenza, or the flu, is a serious lung infection caused by the influenza virus. This virus can lead to widespread illness and death worldwide, causing 3-5 million severe cases and up to 500,000 deaths each year. The flu virus changes over time, leading to seasonal outbreaks and occasional pandemics.
The flu virus is a single-strand RNA virus with eight gene
segments and two key surface proteins, hemagglutinin (HA) and neuraminidase
(NA). HA helps the virus attach to and enter cells, while NA helps the virus
spread by breaking bonds to release new virus particles from infected cells.
Inhibiting these proteins can prevent and treat flu infections.
There are four main antiviral drugs approved by the U.S.
FDA: amantadine, rimantadine, oseltamivir, and zanamivir. However, these drugs
can have side effects and the flu virus can become resistant to them.
Another approach is using antiviral herbal extracts from
medicinal plants. These plants have complex mixtures of ingredients that can
fight the flu virus directly or boost the immune system. This method can also
reduce the side effects associated with single-ingredient drugs. This review
looks at several medicinal plants and their components that show antiviral
activity against the flu
Aloe vera (Aloe barbadensis Mill.)
Aloe vera, belonging to the Asphodelaceae family,
Andrographis (Andrographis paniculata)
Andrographis, from the Acanthaceae family, contains
andrographolide, a compound known for its potential to inhibit the
neuraminidase activity of the H1N1 influenza virus. This makes it a promising
alternative treatment for swine flu. Andrographis has been traditionally used
in Ayurvedic and Chinese medicine for its anti-inflammatory, antibacterial, and
antiviral properties. Studies have shown that it can reduce the severity and
duration of flu symptoms by boosting the immune system and preventing the virus
from spreading. Its ability to combat flu has made it a popular herbal remedy
in many parts of the world, especially during flu outbreaks.
Barberry (Berberis vulgaris)
Barberry, part of the Berberidaceae family, has been used
for centuries to treat various ailments including colds, flu, fever, and
respiratory tract infections. The plant contains berberine, an alkaloid with
significant antimicrobial properties. Berberine is known to inhibit the growth
of bacteria and viruses, making it effective in treating respiratory
infections. Barberry also supports the immune system and has anti-inflammatory
properties, which help alleviate symptoms associated with flu and other
respiratory conditions. Its traditional use in herbal medicine underscores its
effectiveness and safety in treating flu-related symptoms.
Clinacanthus (Clinacanthus siamensis)
Clinacanthus, belonging to the Acanthaceae family, has
demonstrated antiviral activity, particularly against the influenza virus. The
leaf extract of this plant has been studied for its ability to inhibit viral
replication. Traditionally used in Southeast Asian medicine, Clinacanthus is
known for its anti-inflammatory, antiviral, and immune-boosting properties.
Research has shown that it can be effective in reducing the severity of flu
symptoms and speeding up recovery. Its broad-spectrum antiviral activity makes
it a valuable herb in the treatment of influenza and other viral infections.
Echinacea
Echinacea, from the Asteraceae family, is a widely used herb
in treating viral infections, including human and avian influenza viruses like
H3N2 and H1N1. Extracts from Echinacea have shown to boost the immune system,
reduce inflammation, and inhibit viral replication. Studies have indicated that
Echinacea can significantly decrease the severity and duration of flu symptoms.
Its effectiveness against various strains of influenza and its ability to
modulate the immune response make it a popular choice for preventing and
treating colds and flu. Echinacea is often used in combination with other herbs
to enhance its antiviral properties.
Epimedium (Epimedium koreanum)
Epimedium, part of the Berberidaceae family, is used in
traditional Chinese and Korean medicine to combat different subtypes of
influenza A. The plant contains bioactive compounds that have shown significant
antiviral activity, reducing the replication of influenza viruses. Epimedium's
immune-boosting and anti-inflammatory properties help in alleviating flu
symptoms and enhancing the body's resistance to infections. It is often
included in herbal formulations aimed at preventing and treating viral
infections. The use of Epimedium in traditional medicine highlights its
potential as a natural remedy for flu and other respiratory infections.
Flos Lonicerae (Honeysuckle Flower)
Flos Lonicerae, also known as honeysuckle flower, belongs to
the Caprifoliaceae family. It is traditionally used in Chinese medicine to
fight influenza. The flowers contain compounds that have antiviral properties,
making them effective against flu viruses. Honeysuckle is often used to relieve
symptoms like fever and sore throat. Additionally, it has anti-inflammatory and
antioxidant effects, which help boost the immune system and reduce flu-related
discomfort.
Radix Scutellariae (Baical Skullcap Root)
Radix Scutellariae, or Baical skullcap root, is a herb from
the Lamiaceae family. It has been used for centuries in Chinese medicine to
treat respiratory infections, including influenza. The root contains baicalin,
a flavonoid that exhibits strong antiviral activity. This herb helps reduce
inflammation, lowers fever, and boosts the immune response. Its ability to
inhibit flu viruses makes it a valuable natural remedy for flu prevention and
treatment.
Fructus Forsythiae (Forsythia Fruit)
Fructus Forsythiae, or forsythia fruit, is part of the
Oleaceae family. It is commonly used in traditional Chinese medicine for
treating influenza and other respiratory infections. Forsythia fruit has
antiviral, antibacterial, and anti-inflammatory properties. It helps clear heat
and toxins from the body, alleviating symptoms such as fever, sore throat, and
congestion. Its immune-boosting effects make it effective in preventing and
treating flu.
Glechoma Hederacea L. (Ground Ivy)
Glechoma Hederacea, known as ground ivy, belongs to the
Lamiaceae family. This herb is used to treat flu, fever, and respiratory tract
infections. Ground ivy contains compounds that have anti-inflammatory and
antiviral properties. It helps reduce fever and clear mucus from the
respiratory tract, providing relief from flu symptoms. Its ability to soothe
the respiratory system makes it a useful remedy for flu-related cough and
congestion.
Glycyrrhiza Glabra L. (Licorice)
Glycyrrhiza Glabra, or licorice, is a herb from the Fabaceae
family. The major component, glycyrrhetinic acid, has potential as an
anti-influenza virus agent. Licorice root is known for its antiviral,
anti-inflammatory, and immune-boosting properties. It helps soothe sore
throats, reduce coughing, and alleviate other flu symptoms. Licorice is often
used in traditional medicine to enhance the body's resistance to infections,
including the flu.
Camellia Sinensis L. Kuntze (Green Tea)
Camellia Sinensis, commonly known as green tea, is from the
Theaceae family. It is one of the most consumed beverages in Asia. Green tea is
rich in catechins, particularly epigallocatechin gallate (EGCG), which inhibit
the influenza A virus (IAV). The catechins in green tea help prevent flu by
strengthening the immune system and protecting the pharyngeal mucosa. Drinking
green tea regularly can reduce the risk of flu infections and provide overall
health benefits.
Hippophae Rhamnoides L. (Sea Buckthorn)
Hippophae Rhamnoides, known as sea buckthorn, belongs to the
Elaeagnaceae family. The fruits of this plant are used to treat flu, colds, and
infections. Sea buckthorn berries are rich in vitamins, antioxidants, and fatty
acids, which help boost the immune system. They have anti-inflammatory and
antiviral properties that can alleviate flu symptoms and support the body's
natural defense mechanisms. Sea buckthorn is a valuable natural remedy for
maintaining health during flu season.
Hypericum perforatum L. (St. John's Wort)
Hypericum perforatum, commonly known as St. John's Wort,
belongs to the Hypericaceae family. It has been shown to reduce the levels of
the influenza H1N1 virus in infected mice. This is achieved by influencing the
body's production of inflammatory cytokines, which are proteins that help regulate
the immune response. By modulating these cytokines, St. John's Wort can help
control the inflammation caused by the flu, making it a potential treatment
option.
Isatidis radix (Radix Isatidis)
Isatidis radix, part of the Brassicaceae family, is a
traditional Chinese medicine (TCM) used against various influenza viruses. It
is commonly prescribed for symptoms like fever, sore throat, and seasonal
illnesses. The herb's antiviral properties are mainly due to its components,
with progoitrin being the most potent, followed by goitrin, epigoitrin, and
epiprogoitrin. These compounds help combat different strains and subtypes of
the flu virus.
Isatis indigotica Fort. (Ban-Lan-Gen)
Isatis indigotica, another member of the Brassicaceae
family, is used in TCM to treat colds, fever, and sore throats. Its
effectiveness against influenza is due to its alkaloids, such as clemastanin B
and lariciresino-4-β-D-glucopyranoside, which have demonstrated anti-influenza
activity. These compounds help reduce the severity of flu symptoms by
inhibiting the virus.
Lepidium meyenii Walp. (Maca)
Lepidium meyenii, commonly known as Maca, also belongs to
the Brassicaceae family. Extracts from Maca, especially those using methanol,
have antiviral effects similar to the drug amantadine, which is used to treat
influenza. Maca has been shown to inhibit both Influenza A (Flu-A) and
Influenza B (Flu-B) viruses, making it a potential natural treatment for the
flu.
Linum usitatissimum L. (Flaxseed)
Linum usitatissimum, or flaxseed, is from the Linaceae
family. The seeds of this plant are used to treat colds, flu, fever, and
infections. Flaxseed is known for its medicinal properties, which include
boosting the immune system and reducing inflammation, helping to alleviate flu
symptoms and speed up recovery.
Panax ginseng C. A. Meyer (Ginseng)
Panax ginseng, commonly known as ginseng, belongs to the
Araliaceae family. Ginseng is effective in reducing flu symptoms and enhancing
the immune response. It helps by modulating T-helper cells (Th1 and Th2) and
promoting antibody production, which prevents the virus from invading and
replicating. Additionally, it aids in the detachment of the virus from mucous
membranes. Korean red ginseng, in particular, is widely used in Korea for
treating flu-like illnesses.
Petasites hybridus L. (Butterbur)
Butterbur, scientifically known as Petasites hybridus,
belongs to the Asteraceae family. The leaves of this plant are traditionally
used to treat flu, colds, and fever. Butterbur contains compounds that may
reduce inflammation and support respiratory health. It has a long history in
herbal medicine for easing symptoms of respiratory infections and fever. Its
effectiveness is attributed to its anti-inflammatory properties, which can help
soothe the respiratory tract and alleviate flu symptoms. Butterbur is often
used in herbal teas or supplements to provide relief from common cold and flu
symptoms.
Phoenix sylvestris Roxb (Indian Date)
Phoenix sylvestris, commonly known as the Indian date, is
part of the Arecaceae family. The fresh sap of this plant is rich in vitamin C,
which is essential for immune system function. This sap is particularly useful
in treating colds, fever, and sore throats. Vitamin C helps boost the immune
system and can reduce the duration and severity of respiratory infections.
Drinking the fresh sap or using it in various remedies can help soothe the
throat and provide relief from cold and flu symptoms. Indian date is valued for
its natural antiviral and immune-boosting properties.
Pimpinella major (L.) Hudson (Greater Burnet Saxifrage)
Greater Burnet Saxifrage, or Pimpinella major, is a member
of the Apiaceae family. The root of this plant is used in traditional medicine
to treat colds, flu, and fever. It contains active compounds that may help
reduce fever and alleviate respiratory symptoms. By using the root in teas or
extracts, it can provide relief from flu symptoms and support overall
respiratory health. The plant's medicinal properties are mainly due to its
anti-inflammatory and fever-reducing effects, making it a valuable herb in
managing flu and cold symptoms.
Pithecellobium clypearia (Jack) Benth.
Pithecellobium clypearia is a plant in the Fabaceae family.
Its leaves contain flavan derivatives that have shown activity against
respiratory syncytial virus and the influenza virus H1N1. These compounds help
inhibit the replication of viruses, making the plant effective in fighting
respiratory infections. Traditional uses of this plant focus on its antiviral
properties, providing a natural remedy for flu and related respiratory
illnesses. The leaves are typically used in herbal preparations to boost the
immune system and combat viral infections.
Psidium guajava Linn (Guava)
Guava, scientifically known as Psidium guajava, is from the
Myrtaceae family. Guava tea is made from the leaves of the plant and is known
to inhibit viral hemagglutination and sialidase activity, which are crucial for
the influenza virus's ability to infect cells. It also inhibits the growth of
influenza A (H1N1). Guava leaves contain compounds that boost the immune system
and provide antiviral effects, making guava tea a popular remedy for flu
symptoms. Drinking guava tea can help reduce the severity and duration of flu
infections.
Punica granatum L. (Pomegranate)
Pomegranate, or Punica granatum, belongs to the Punicaceae
family. It has shown anti-influenza properties by suppressing the replication
of the influenza A virus in cell culture studies. The fruit contains
antioxidants and other compounds that help boost the immune system and inhibit
viral activity. Consuming pomegranate juice or extracts can help prevent the
spread of the flu virus and support overall health during an infection.
Pomegranate is valued for its antiviral properties and its ability to enhance
immune function.
Radix bupleuri (Bupleurum Root)
Bupleurum root, known scientifically as Radix bupleuri, is
part of the Apiaceae family. It is used in traditional medicine to treat
influenza and upper respiratory infections. The root contains active compounds
that have antiviral and anti-inflammatory effects, helping to reduce fever and
alleviate symptoms of respiratory infections. Bupleurum root is often used in
herbal formulas and teas to support immune health and combat flu symptoms. Its
medicinal properties make it a common ingredient in natural remedies for colds
and flu.
Elderberry (Sambucus nigra L.):
Elderberry fruits and flowers are used to treat viral
infections like flu and colds.
Chinese Skullcap (Scutellaria baicalensis Gorgi):
This herb may help fight influenza by killing infected cells
and inhibiting the flu virus from spreading.
Agathi (Sesbania grandiflora L. Poiret):
Agathi leaves are full of nutrients and can be used as an
antimicrobial agent against colds and flu.
Rowan (Sorbus aucuparia L.):
The fruits of this plant are used to treat fever, colds, and
flu.
Prunella vulgaris L.:
This herb is used to fight influenza.
White Mulberry (Morus alba L.):
White Mulberry leaves can control blood sugar levels,
prevent fat buildup, and fight infections, including influenza.
Chinese Mahogany (Toonasinensis):
The leaves of this plant prevent influenza by stopping the
virus from attaching to cells.
Ajwain (Trachyspermum ammi L.):
Ajwain seeds are
mixed with clove and salt to treat throat inflammation during influenza, and
inhaling crushed seeds helps with a common cold.
Gegen Qinlian decoction:
This Chinese medicine formula helps balance the body's
response to inflammation caused by influenza, improving outcomes and survival.
Ge Gen decoction:
A famous traditional
Chinese medicine, it treats common colds and has anti-influenza properties,
soothing lung inflammation.
IMOD and Arbidol combination:
This novel medicine combines a natural immunomodulator with
a synthetic antiviral to prevent and treat various types of influenza and flu.
Jinchai:
This traditional Chinese medicine contains herbs like honeysuckle
and astragalus, which fight influenza viruses.
Rorrico:
This extract, made from a blend of 21 Chinese herbs, is
effective against influenza, including the H1N1 swine flu virus.
Yi-Zhi-Hao pellet (CYZH):
This traditional formula has broad-spectrum anti-influenza
properties, inhibiting the virus's replication.
Xin-Jia-Xiang-Ru-Yin:
This Chinese herbal compound is used to treat summer
influenza
Traditional medicinal plants have been used to treat the flu
in many regions, including Asia, Eastern Europe, North America, and parts of
South America. Some of these plants are Echinacea purpurea, Cistus incanus,
Geranium sanguineum, Glycyrrhiza uralensis, and Ephedra herba. These plants
have chemicals like polyphenols and aromatic compounds that might help stop the
flu virus. Some flavonoids in these plants could also help reduce flu symptoms
by acting against the virus.
Reference
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